Pre-clinical toxicology facility is well equipped to support discovery, clinical candidate selection and early development programs with the following capabilities
In vivo toxicology:
- Dermal toxicity studies in rats and rabbits:
- Acute studies
- Repeat-dose studies (14 days)
- Oral toxicity studies in mice, rats and rabbits:
- Acute studies
- Repeat-dose studies (4 Days, 7 Days & 14 Days)
- Histopathology support to efficacy and toxicity studies
- Toxicokinetics
- Rodent radiography study for joint deformities
- Micronucleus test in mice and rats
In vitro toxicology:
- Ames test
- Chromosomal aberration test
- Mouse lymphoma test
- Comet assay
Compliance:
Regulatory guidelines such as ICH, OECD and USFDA are followed to conduct the toxicity studies. All animal experimentation is performed according to the approved protocol from IAEC as per CPCSEA guidelines.